Contrave – combination of Naltrexone and Buprion

Contrave diet drugContrave is a weight loss drug that has been available in the USA since 2014 and in the UK since 2015. A doctor’s prescription is required in both countries. Contrave cannot be bought over-the-counter.

Doctors who need to treat obese patients have a number of drugs at their disposal and most of them, including Orlistat and Belviq, only contain one active ingredient.

Contrave is a little different because each capsule provides a combination of the drugs Naltrexone and Buprion.

Both drugs work on the mind rather than the body and, when used individually, they appear to support the weight loss process.

When combined they work in a synergetic way, and each enhances the other’s abilities, but both drugs have been linked to side effects so it is not surprising that their pairing has resulted in a drug that can prove to be problematic to some users.

Contrave and Its Potential

Science of ContraveA comparison of scientific study results suggests Contrave may be more powerful than the prescription weight loss drug Belviq, but not as effective as Qsymia.

When compared, the data showed the use of Belviq had encouraged a weight loss of 3%, but volunteers using Qsymia had reduced their weight by 9%, suggesting it may be three times more powerful than Belviq.

Contrave was somewhere in the middle, with users showing an average weight reduction of 5%.

Read about which diet pills are available to buy without prescription in Australia

What is Contrave and How Does it Work?

appetite for foodContrave appears to be capable of influencing the neural activity that relates to feelings of hunger and reducing the desire for food.

It’s ability to provide appetite suppression was tested in a number of clinical trails, involving 4,500 obese volunteers (with and without weight-related health problems).

All the volunteers exercised regularly and consumed a restricted calorie diet during the 12-month study period.

At the end of the study the Contrave group members showed an average weight loss that was 4.1% higher than the members of the placebo group.

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How to Take Contrave – capsules must be swallowed whole and they should never be consumed alongside high fat meals or alcohol as this increases the likelihood of seizure. Four capsules are required per day, but new users need to reduce the dosage and work their way up to the full dose over a four-week period.

  • Week 1: One capsule every morning.
  • Week 2: One capsule in the morning, followed by a second capsule during the evening.
  • Week 3: Two capsules in the morning followed by a second capsule during the evening.
  • Week 4 onward: Two capsules in the morning followed by two further capsules during the evening.

Who is Contrave for?

Contrave is only approved for use by people who are making a serious effort to lose weight, so the drug must be used alongside diet and exercise.

Patients also need to have gained a significant amount of weight in order to qualify for a prescription and other considerations may need to be taken into account.

Contrave might not be suitable for people who suffer from certain medical conditions, or are using specific medications, but anyone who has a BMI of 30 or higher may be eligible for a Contrave prescription.

The official guidelines also permit people with a slightly lower level of obesity (BMI 27+) to qualify for a prescription, but only if they also have a health condition, such as high blood pressure, that may improve if they were to successfully slim down.

Suitability Issues

Contrave is not intended for women who are pregnant or for people who suffer from eating disorders, such as anorexia or bulimia.

Nor is is suitable for anyone who suffers from seizures, has high blood pressure, a history of cardiovascular problems, or certain other medical conditions. People who are taking some types of medication may also be unable to try and lose weight with Contrave.

Contrave Side Effects

Contrave is capable of causing a number of side effects and some of them are particularly worrying:

  • Severe allergic reaction
  • Increases in blood pressure
  • Racing heart
  • Liver damage or hepatitis
  • Manic episodes
  • Thoughts of suicide
  • Visual problems and pain to the eyeballs

More commonly encountered problems include:

  • Constipation
  • Nausea
  • Dizziness
  • Vomiting
  • Headache
  • Difficulty sleeping
  • Dry mouth
  • Diarrhoea

Contrave in a Nutshell

appetite suppressants AustraliaContrave is a prescription weight loss drug that is only prescribed to people who have a high degree of obesity.

It has proven to be an effective appetite suppressant, but it is not suitable for people who are taking some types of medication or have certain medical conditions. Contrave usage has also be linked to numerous side effects, some of which are quite serious.

Read more about Appetite Suppressants here

SignaLEAN Review – can you really eat less

SignaLean ReviewSignLean is a supplement marketed by Purity Products.

It is produced in tablet format and utilizes plants sterols and potato extracts.

The formulation has been designed to help support people who are trying to lose weight and lower their cholesterol levels at the same time, so it is very different from most of the other weight loss supplements on the market.

The three promised benefits are:

  • Manages Appetite and Hunger
  • Supports Healthy Body Weight
  • Supports Healthy Cholesterol Levels

However, Purity Products point out the level of weight lost is unlikely to exceed one to two pounds per week and stress the importance of using the tablets in conjunction with a low calorie diet and exercise. Many people have lost far more weight than this through diet and exercise alone.

What Is In SignLean

Each SignLean tablet provides:

Potato Protein Extract [Proteinase Inhibitors (P12) tubers] (15 mg)

Potato ProteinPurity products draws attention to the fact that this particular form of potato-provided protein has been subjected to clinical trials that support its ability to trigger a process that causes the stomach to send a chemical signal to the brain that suggests there is no further need for food. This is true enough.

Researchers at Rutgers University in New Brunswick (USA) conducted such a study in 2010 and affirmed potato protein’s ability to provide appetite suppression. However, the study in question was conducted on laboratory rats. The effects on the human body may be quite different. There was also a considerable difference in the dosages involved. The researchers administered a dose that provided a daily dose of 100mg potato protein per 1kg of body weight. That means a 75kg human would need to consume 7.5g of potato protein per day to attain similar results. At just 15mg, the amount provided here is significantly less.

Pytosterols (400mg)[from 421 mg of CadioAid (from vegetable oils) Total phytosterols minimum 95% 400 mg with typical profile: B-Sitosterol 40-58%, Campesterol 20-30%, Stigmasterol 14-22%, Brassicasterol 0-6% and Sitostanol 0-5%.

Phytosterols are naturally-occurring compounds sourced from plant cell membranes. Purity Products states the use of these sterols have been proven capable of supporting healthy cholesterol levels and may help reduce the chances of heart disease. Once again the claims made for the ingredient are valid and this time the amount used is more than adequate. But elevated cholesterol levels can pose such a serious risk to the health it would be unwise to attempt to rectify the problem without first seeking the advice of a doctor. However, the doctor may choose to prescribe an alternative option rather than sanction the use of supplement like SignLean.

How to Take SignLean – One tablet is required twice per day and doses should be consumed 30-60 minutes before the two largest meals. Purity Products also suggests taking double the normal dose during the first 15 days of use.

SignLean Customer Feedback

At the time of this review, the manufacturer’s website provided two pages of customer reviews. The first page contained only 5-star ratings, but the second page provided several 2-star and 4-star reviews left by customers who stated the product failed to meet their expectations.

Possible SignLean Side Effects & Health Issues

Purity Products says people who suffer from high cholesterol, or are taking cholesterol medication, should check with their doctor before using SignLean. They fail to mention if side effects are likely, but phytosterols are known to be problematic to a small percentage of users. Possible side effects can include mild bloating, changes in bowel movement, and stomach pain.

Guarantee

SignLean is sold with a 60-day money back guarantee.

Where To Buy SignLean

Each bottle of SignLean contains 60 tablets and has a price tag of $44. Customers who buy 4 bottles at the normal price will receive an extra bottle free of charge. Purity Products also offers significant discounts to customers who order 12-95 bottles, a fact that suggests they are hoping to parner with third-party sellers and online stores.

It is also possible to purchase SignLean via Purity Products’ “Super Saver” option and receive a 25% discount on the normal price of the product as a reward for signing up for their automated billing and shipping program. Customers who do so will receive a fresh supply of pills every month and the cost will be automatically applied to the card that was used to place the original order.

Automated shipping options are becoming increasingly common these days because manufactures can use them to generate a steady stream of income. However, once such an agreement has been made it can sometimes be hard to cancel and some manufacturers trick people into signing-up for them without realizing they are doing so. Purity Products does not use such despicable tactics. The Super Saver option is just that (an option), but it is generally better to avoid buying diet pills via such a method. If the pills work a regular supply will not be required and, if they do not, getting a fresh batch each month is waste of time and money.

Looking Elsewhere – Other Appetite Suppressants

Suppressing appetiteAppetite suppressants are definitely recommended, they are one of the top three genres of diet pills.

There are products that not only suppress appetite but also burn fat.

Read more on appetite suppressants and multi action diet pills here

Ketovox – Fat Burner and Appetite Suppressant

Ketovox reviewJudging by its distinctive pink and white bottle, Ketovox diet pills appear to be marketed towards women rather than men. The product is also shrouded in mystery because it appears to be solely marketed via the Fit Solution Nutrition online store and the sales page fails to disclose the identity of the manufacturer, the required dosage, possible side effects, ingredient inclusion rates, or how the product is designed to work.

However, what the page lacks in information, it make up for with spiel.

According to the Ketovox sales page the product is:

  • Backed by solid science
  • Provides safe weight loss quickly
  • Is the hottest weight loss pill
  • Delivers fat burning, appetite suppression and high energy

What is Ketovox and What does it Do?

Judging by the statements above, the formulation appears to be designed to speed up the metabolism and encourage fat burning while also ensuring a lowered calorie intake by helping to keep eating habits under control. Any number of other products are designed to work in the same way, so this is nothing new.

Key Ingredients & Blend Potential

In all fairness to Fit Solution Nutrition, they do provide quite a bit of information about the five ingredients that power the Ketovox blend. Unfortunately it all means nothing without an idea of the weights and ratios involved. It is also worth noting the present formulation is very different to that shown on other review sites, so the blend has been completely changed at least once.

Raspberry ketones seems to take top-billing as the main ingredient in the present formulation and the sales page states its abilities are supported by five more ingredients, but only lists four. So either there has been an error in counting or the present blend contains an undisclosed ingredient.

The Ketovox weight loss formulation contains:

  • Raspberry Ketones: Scientific research suggests supplementation with raspberry ketones can result in increased adiponectin levels. When the availability of this form of protein is increased the appetite is suppressed and chemical changes occur in the body that ultimately result in an improved ability to burn fat. Raspberry Ketones is a good ingredient and it performed very well when the American weight loss expert Dr Oz put it through its paces on National TV. However, raspberry ketones is an incredibly expensive ingredient, so many manufacturers scrimp on inclusion rates or use sub-standard synthetic forms; so the fact that no inclusion rate is provided is a major issue.
  • L-Carnitine: An amino acid that is manufactured within the body, but is often included in supplements that are designed to provide weight loss or improved muscle growth. Some studies suggest it has the ability to boost energy levels and provide a feeling of improved vitality. L-carnitine is also an antioxidant that can offer protection against the damaging effects of the free radicals (toxins) found in some foods.
  • Maqui Berry Extract: An ingredient that is derived from the fruit of an evergreen shrub that is native to Chile and Argentina. It is credited with several medicinal benefits, and is a good source of antioxidants, but the claims made for its potential as a weight loss aid cannot be supported by sufficient scientific proof.
  • Alpha Lipoic Acid (ALA): A vitamin-like ingredient that is known to be an antioxidant. It is naturally occurring in broccoli, potatoes, liver, and many other foods and can also be manufactured in a laboratory. The body uses ALA to assist the breakdown of carbohydrates, so it can have value as an energy provider.
  • Green Coffee Bean Extract: The chlorogenic acid provided by green coffee beans is renowned for its fat burning abilities, so it is not unusual to see green coffee bean extract used as a standalone weight loss provider. The dosage used in most scientific studies ranges from 120-300mg, but how this compares to the amount used here is anybody’s guess.
How to Take Ketovox – We were unable to find any information about the required dosage or any instructions regarding the product’s use other than the pills should be used in conjunction with diet and exercise

Ketovox Customer Feedback

The only customer feedback available comes courtesy of the site selling the product and is highly suggestive of a weight loss product that works. But reviews and testimonials gathered from sites that have a vested interest in any product’s reputation can never be relied upon to be wholly accurate or unbiased.

Possible Side Effects Of Ketovox

No side effects are mentioned, but the formulation is unlikely to be suitable for pregnant or nursing mothers. People who have existing health issues, or are using medication, should always consult with their doctor prior to using any brand of weight loss supplement.

Is There a Guarantee

The manufacturer does not offer a money back guarantee, but Fit Solution Nutrition does and it is good for 90 days.

Where To Order Ketovox

A bottle of Ketovox diet pills costs $39.95 from the Fit Solution Nutrition online store. Customers who purchase two or more bottles receive a discount and an auto-ship option is also available that allows customers to get their pills at a discounted price if they agree to receive a fresh shipment of pills every month.

Our Recommendation

recommended diet pillsIf your intention is to buy a multi focused diet product then we would strongly recommend PhenQ. PhenQ can suppress your appetite as well at block and burn fat deposits.

Phenq is particularly interesting due to its 60 day money back guarantee and its free shipping policy anywhere in the world .. including Australia.

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